Two Left Feet
In doubles, when you have a player who is left-handed, while the partner is right-handed, it is like an individual trying to dance with two left feet. You will see that this team will be consistently flummoxed with shots down the middle, unless they have determined in advance who is going to be dominant in returning shots that go between them.
Analyzing the effect a step further, if their dominant hands are facing the middle, they’ll tend to crash or at least interfere with each other. In the opposite situation, they will both let their partner take the shot, resulting, of course, in no one taking the shot, or one player taking it badly at the last possible moment.
When they are situated so that both of their dominant hands are toward each other, you can play with diagonals, since neither will be especially strong in returning shots near the sidelines.